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Functional role of type I and type II interferons in antiviral defense.

Science (New York, N.Y.) | Jun 24, 1994

Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.

Pubmed ID: 8009221 RIS Download

Mesh terms: Alphavirus Infections | Animals | Antibodies, Viral | Disease Susceptibility | Immunity, Innate | Interferon Type I | Interferon-gamma | Lymphocytic Choriomeningitis | Membrane Proteins | Mice | Mutation | Receptor, Interferon alpha-beta | Receptors, Interferon | Rhabdoviridae Infections | Semliki forest virus | Signal Transduction | T-Lymphocytes | Vesicular stomatitis Indiana virus | Virus Diseases