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Functional role of type I and type II interferons in antiviral defense.

Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.

Pubmed ID: 8009221

Authors

  • Müller U
  • Steinhoff U
  • Reis LF
  • Hemmi S
  • Pavlovic J
  • Zinkernagel RM
  • Aguet M

Journal

Science (New York, N.Y.)

Publication Data

June 24, 1994

Associated Grants

None

Mesh Terms

  • Alphavirus Infections
  • Animals
  • Antibodies, Viral
  • Disease Susceptibility
  • Immunity, Innate
  • Interferon Type I
  • Interferon-gamma
  • Lymphocytic Choriomeningitis
  • Membrane Proteins
  • Mice
  • Mutation
  • Receptor, Interferon alpha-beta
  • Receptors, Interferon
  • Rhabdoviridae Infections
  • Semliki forest virus
  • Signal Transduction
  • T-Lymphocytes
  • Vesicular stomatitis Indiana virus
  • Virus Diseases