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Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.

Cell | Dec 30, 1994

http://www.ncbi.nlm.nih.gov/pubmed/8001151

Peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) is an adipocyte-specific nuclear hormone receptor that has recently been identified as a key regulator of two fat cell enhancers. Transcriptional activation by PPAR gamma 2 is potentiated by a variety of lipids and lipid-like compounds, including naturally occurring polyunsaturated fatty acids. We demonstrate here that retroviral expression of PPAR gamma 2 stimulates adipose differentiation of cultured fibroblasts. PPAR activators promote the differentiation of PPAR gamma 2-expressing cells in a dose-dependent manner. C/EBP alpha, a second transcription factor induced during adipocyte differentiation, can cooperate with PPAR gamma 2 to stimulate the adipocyte program dramatically. Our results suggest that the physiologic role of PPAR gamma 2 is to regulate development of the adipose lineage in response to endogenous lipid activators and that this factor may serve to link the process of adipocyte differentiation to systemic lipid metabolism.

Pubmed ID: 8001151 RIS Download

Mesh terms: 3T3 Cells | Adipocytes | Animals | Base Sequence | CCAAT-Enhancer-Binding Proteins | Cell Differentiation | Cell Line | DNA-Binding Proteins | Fatty Acids | Fibroblasts | Gene Expression Regulation | Mice | Mice, Inbred BALB C | Molecular Sequence Data | Mutation | Nuclear Proteins | Receptors, Cytoplasmic and Nuclear | Recombinant Proteins | Transcription Factors

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Associated grants

  • Agency: NIDDK NIH HHS, Id: DK31405
  • Agency: NIGMS NIH HHS, Id: T32 GM007753
  • Agency: NIGMS NIH HHS, Id: T32 GM07753

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