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Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene.

Cell | Dec 2, 1994

http://www.ncbi.nlm.nih.gov/pubmed/8001115

The beta-amyloid precursor protein (beta APP) gene of the mouse was disrupted by inserting into exon 2 a cassette containing a neomycin resistance gene and a putative transcription termination sequence. Contrary to expectation, brain and other tissues from mice homozygous for the insertion still contained beta APP-specific RNA, albeit at a level 5- to 10-fold lower than wild type and lacking the disrupted exon, which had been spliced out. The brain contained shortened beta APP-specific protein at a low level. Mutant mice were severely impaired in spatial learning and exploratory behavior and showed increased incidence of agenesis of the corpus callosum.

Pubmed ID: 8001115 RIS Download

Mesh terms: Amyloid beta-Protein Precursor | Animals | Base Sequence | Behavior, Animal | Brain | Exons | Exploratory Behavior | Female | Gene Expression | Homozygote | Learning | Male | Mice | Mice, Mutant Strains | Molecular Sequence Data | Mutagenesis, Insertional | RNA, Messenger | Spatial Behavior

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Mouse Genome Informatics (Data, Gene Annotation)

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