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Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.


The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor eIF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with eIF-4E inhibits translation but treatment of cells with insulin causes one of them to become hyperphosphorylated and dissociate from eIF-4E, thereby relieving the translational inhibition. The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth.

Pubmed ID: 7935836


  • Pause A
  • Belsham GJ
  • Gingras AC
  • DonzĂ© O
  • Lin TA
  • Lawrence JC
  • Sonenberg N



Publication Data

October 27, 1994

Associated Grants


Mesh Terms

  • Acid Phosphatase
  • Adaptor Proteins, Signal Transducing
  • Adipose Tissue
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins
  • Cell Line
  • Cloning, Molecular
  • DNA, Complementary
  • Escherichia coli
  • Eukaryotic Initiation Factor-4E
  • Humans
  • Insulin
  • Male
  • Molecular Sequence Data
  • Peptide Initiation Factors
  • Phosphoproteins
  • Phosphorylation
  • Protein Binding
  • Protein Biosynthesis
  • RNA Caps
  • Rabbits
  • Rats
  • Rats, Sprague-Dawley
  • Sequence Homology, Amino Acid