Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

Genes & development | May 1, 1994

http://www.ncbi.nlm.nih.gov/pubmed/7926783

We have established a targeted loss-of-function mutation in the RXR alpha gene in the mouse germ line that results in embryonic lethality between E13.5 and E16.5 when bred to homozygosity. The major defect responsible for lethality is hypoplastic development of the ventricular chambers of the heart, which is manifest as a grossly thinned ventricular wall with concurrent defects in ventricular septation. This phenotype is identical to a subset of the effects of embryonic vitamin A deficiency and, therefore, establishes RXR alpha as a genetic component of the vitamin A signaling pathway in cardiac morphogenesis. The cardiac outflow tracts and associated vessels, which are populated by derivatives of the neural crest and which are also sensitive to vitamin A deficiency, are normal in homozygous embryos, indicating the genetic independence of ventricular chamber development. Hepatic differentiation was dramatically but transiently retarded yet is histologically and morphologically normal. These results ascribe an essential function for the RXR alpha gene in embryonic development and provide the first evidence of a requirement for RXR in one of its predicted hormone response pathways.

Pubmed ID: 7926783 RIS Download

Mesh terms: Animals | Embryonic and Fetal Development | Female | Fetal Heart | Gene Targeting | Germ-Line Mutation | Heart Ventricles | Homozygote | Liver | Male | Mice | Mice, Inbred C57BL | Mice, Transgenic | Morphogenesis | Phenotype | Receptors, Cytoplasmic and Nuclear | Receptors, Retinoic Acid | Retinoid X Receptors | Signal Transduction | Transcription Factors | Vitamin A

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NCI NIH HHS, Id: CA54418
  • Agency: NHLBI NIH HHS, Id: HL-46345
  • Agency: NHLBI NIH HHS, Id: HL-51549

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.