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Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock.

Cell | Feb 10, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7859282

IL-1 beta-converting enzyme (ICE) cleaves pro-IL-1 beta to generate mature IL-1 beta. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/lch-1. We generated ICE-deficient mice and observed that they are overtly normal but have a major defect in the production of mature IL-1 beta after stimulation with lipopolysaccharide. IL-1 alpha production is also impaired. ICE-deficient mice are resistant to endotoxic shock. Thymocytes and macrophages from the ICE-deficient animals undergo apoptosis normally. ICE therefore plays a dominant role in the generation of mature IL-1 beta, a previously unsuspected role in production of IL-1 alpha, but has no autonomous function in apoptosis.

Pubmed ID: 7859282 RIS Download

Mesh terms: Animals | Apoptosis | Base Sequence | Caspase 1 | Chimera | Cysteine Endopeptidases | Cytokines | Female | Interleukin-1 | Lipopolysaccharides | Macrophage Activation | Macrophages, Peritoneal | Male | Mice | Mice, Inbred C57BL | Molecular Sequence Data | RNA, Messenger | Sequence Deletion | Shock, Septic | Thymus Gland

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Mouse Genome Informatics (Data, Gene Annotation)

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