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Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.


Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an animal model of MAOA deficiency. In pup brains, serotonin concentrations were increased up to ninefold, and serotonin-like immunoreactivity was present in catecholaminergic neurons. In pup and adult brains, norepinephrine concentrations were increased up to twofold, and cytoarchitectural changes were observed in the somatosensory cortex. Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine. Adults manifested a distinct behavioral syndrome, including enhanced aggression in males.

Pubmed ID: 7792602


  • Cases O
  • Seif I
  • Grimsby J
  • Gaspar P
  • Chen K
  • Pournin S
  • M├╝ller U
  • Aguet M
  • Babinet C
  • Shih JC


Science (New York, N.Y.)

Publication Data

June 23, 1995

Associated Grants

  • Agency: NIMH NIH HHS, Id: K05 MH 00796
  • Agency: NIMH NIH HHS, Id: R01 MH 37020
  • Agency: NIMH NIH HHS, Id: R37 MH 39085
  • Agency: NIMH NIH HHS, Id: R37 MH039085
  • Agency: NIMH NIH HHS, Id: R37 MH039085-23

Mesh Terms

  • Aggression
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Southern
  • Brain
  • Disease Models, Animal
  • Dopamine
  • Female
  • Interferon-beta
  • Male
  • Mice
  • Mice, Inbred C3H
  • Mice, Transgenic
  • Molecular Sequence Data
  • Monoamine Oxidase
  • Norepinephrine
  • Sequence Deletion
  • Serotonin