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Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene.

Gene | Apr 3, 1995

The human poliovirus (PV) receptor (PVR) is a member of the immunoglobulin (Ig) superfamily with unknown cellular function. We have isolated a human PVR-related (PRR) cDNA. The deduced amino acid (aa) sequence of PRR showed, in the extracellular region, 51.7 and 54.3% similarity with human PVR and with the murine PVR homolog, respectively. The cDNA coding sequence is 1.6-kb long and encodes a deduced 57-kDa protein; this protein has a structural organization analogous to that of PVR, that is, one V- and two C-set Ig domains, with a conserved number of aa. Northern blot analysis indicated that a major 5.9-kb transcript is present in all normal human tissues tested. In situ hybridization showed that the PRR gene is located at bands q23-q24 of human chromosome 11.

Pubmed ID: 7721102 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Base Sequence | Carcinoma | Chromosome Mapping | Chromosomes, Human, Pair 11 | Cloning, Molecular | DNA, Complementary | Humans | Membrane Proteins | Mice | Molecular Sequence Data | Receptors, Virus | Sequence Alignment | Tumor Cells, Cultured | Urinary Bladder Neoplasms

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