Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production.

Nature genetics | Feb 24, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7719350

Chronic granulomatous disease (CGD) is a recessive disorder characterized by a defective phagocyte respiratory burst oxidase, life-threatening pyogenic infections and inflammatory granulomas. Gene targeting was used to generate mice with a null allele of the gene involved in X-linked CGD, which encodes the 91 kD subunit of the oxidase cytochrome b. Affected hemizygous male mice lacked phagocyte superoxide production, manifested an increased susceptibility to infection with Staphylococcus aureus and Aspergillus fumigatus and had an altered inflammatory response in thioglycollate peritonitis. This animal model should aid in developing new treatments for CGD and in evaluating the role of phagocyte-derived oxidants in inflammation.

Pubmed ID: 7719350 RIS Download

Mesh terms: Alleles | Animals | Aspergillosis | Aspergillus fumigatus | Cytochrome b Group | Disease Models, Animal | Female | Genetic Linkage | Granulomatous Disease, Chronic | Lung Diseases, Fungal | Macrophages | Male | Mice | Mice, Inbred C57BL | Mice, Transgenic | Neutrophils | Peritonitis | Phagocytes | Staphylococcal Infections | Staphylococcus aureus | Stem Cells | Superoxides | X Chromosome

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.