Literature search services are currently unavailable. During our hosting provider's UPS upgrade we experienced a hardware failure and are currently working to resolve the issue.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.

Association of the c-erbB-2 oncogene product with the cadherin-catenin complex has been demonstrated in human cancer cell lines. Although beta-catenin and plakoglobin have been proven to be crucial for the association, no previous study has shown whether the interactions are direct or indirect. In the present study, the c-erbB-2 gene product was shown by far-Western blotting analysis to associate directly with both beta-catenin and plakoglobin through its cytoplasmic domain core region, which showed extensive homology with epidermal growth factor receptor. These data suggest that c-erbB-2-induced signaling is also directly liked to the cadherin-mediated cell adhesion and "invasion-suppressor" system through beta-catenin and plakoglobin in cancers.

Pubmed ID: 7702605


  • Kanai Y
  • Ochiai A
  • Shibata T
  • Oyama T
  • Ushijima S
  • Akimoto S
  • Hirohashi S


Biochemical and biophysical research communications

Publication Data

March 28, 1995

Associated Grants


Mesh Terms

  • Adenocarcinoma
  • Blotting, Western
  • Cadherins
  • Cell Adhesion Molecules
  • Cloning, Molecular
  • Cytoskeletal Proteins
  • Desmoplakins
  • Genes, erbB-2
  • Glutathione Transferase
  • Humans
  • Protein Binding
  • Receptor, Epidermal Growth Factor
  • Receptor, ErbB-2
  • Recombinant Fusion Proteins
  • Sequence Homology, Amino Acid
  • Stomach Neoplasms
  • Trans-Activators
  • Tumor Cells, Cultured
  • beta Catenin
  • gamma Catenin