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c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.

Association of the c-erbB-2 oncogene product with the cadherin-catenin complex has been demonstrated in human cancer cell lines. Although beta-catenin and plakoglobin have been proven to be crucial for the association, no previous study has shown whether the interactions are direct or indirect. In the present study, the c-erbB-2 gene product was shown by far-Western blotting analysis to associate directly with both beta-catenin and plakoglobin through its cytoplasmic domain core region, which showed extensive homology with epidermal growth factor receptor. These data suggest that c-erbB-2-induced signaling is also directly liked to the cadherin-mediated cell adhesion and "invasion-suppressor" system through beta-catenin and plakoglobin in cancers.

Pubmed ID: 7702605 RIS Download

Mesh terms: Adenocarcinoma | Blotting, Western | Cadherins | Cell Adhesion Molecules | Cloning, Molecular | Cytoskeletal Proteins | Desmoplakins | Genes, erbB-2 | Glutathione Transferase | Humans | Protein Binding | Receptor, Epidermal Growth Factor | Receptor, ErbB-2 | Recombinant Fusion Proteins | Sequence Homology, Amino Acid | Stomach Neoplasms | Trans-Activators | Tumor Cells, Cultured | beta Catenin | gamma Catenin