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c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.

Association of the c-erbB-2 oncogene product with the cadherin-catenin complex has been demonstrated in human cancer cell lines. Although beta-catenin and plakoglobin have been proven to be crucial for the association, no previous study has shown whether the interactions are direct or indirect. In the present study, the c-erbB-2 gene product was shown by far-Western blotting analysis to associate directly with both beta-catenin and plakoglobin through its cytoplasmic domain core region, which showed extensive homology with epidermal growth factor receptor. These data suggest that c-erbB-2-induced signaling is also directly liked to the cadherin-mediated cell adhesion and "invasion-suppressor" system through beta-catenin and plakoglobin in cancers.

Pubmed ID: 7702605


  • Kanai Y
  • Ochiai A
  • Shibata T
  • Oyama T
  • Ushijima S
  • Akimoto S
  • Hirohashi S


Biochemical and biophysical research communications

Publication Data

March 28, 1995

Associated Grants


Mesh Terms

  • Adenocarcinoma
  • Blotting, Western
  • Cadherins
  • Cell Adhesion Molecules
  • Cloning, Molecular
  • Cytoskeletal Proteins
  • Desmoplakins
  • Genes, erbB-2
  • Glutathione Transferase
  • Humans
  • Protein Binding
  • Receptor, Epidermal Growth Factor
  • Receptor, ErbB-2
  • Recombinant Fusion Proteins
  • Sequence Homology, Amino Acid
  • Stomach Neoplasms
  • Trans-Activators
  • Tumor Cells, Cultured
  • beta Catenin
  • gamma Catenin