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Requirement for Lim1 in head-organizer function.

Nature | Mar 30, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7700351

Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer.

Pubmed ID: 7700351 RIS Download

Mesh terms: Animals | Base Sequence | Biological Markers | Brain | DNA Primers | Embryonic Induction | Embryonic and Fetal Development | Gene Deletion | Gene Expression | Gene Targeting | Genes, Homeobox | Head | Homeodomain Proteins | LIM-Homeodomain Proteins | Mesoderm | Mice | Mice, Inbred C57BL | Molecular Sequence Data | Phenotype | Stem Cells | Transcription Factors

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Mouse Genome Informatics (Data, Gene Annotation)

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