Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Requirement for Lim1 in head-organizer function.

Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer.

Pubmed ID: 7700351


  • Shawlot W
  • Behringer RR



Publication Data

March 30, 1995

Associated Grants


Mesh Terms

  • Animals
  • Base Sequence
  • Biological Markers
  • Brain
  • DNA Primers
  • Embryonic Induction
  • Embryonic and Fetal Development
  • Gene Deletion
  • Gene Expression
  • Gene Targeting
  • Genes, Homeobox
  • Head
  • Homeodomain Proteins
  • LIM-Homeodomain Proteins
  • Mesoderm
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Phenotype
  • Stem Cells
  • Transcription Factors