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Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death.

Nature genetics | Jul 18, 1995

We report the generation and characterization of mice lacking adenosine deaminase (ADA). In humans, absence of ADA causes severe combined immunodeficiency. In contrast, ADA-deficient mice die perinatally with marked liver-cell degeneration, but lack abnormalities in the thymus. The ADA substrates, adenosine and deoxyadenosine, are increased in ADA-deficient mice. Adenine deoxyribonucleotides are only modestly elevated, whereas S-adenosylhomocysteine hydrolase activity is reduced more than 85%. Consequently, the ratio of S-adenosylhomocysteine (AdoMet) to S-adenosyl homocysteine (AdoHcy) is reduced threefold in liver. We conclude that ADA plays a more critical role in murine than human fetal development. The murine liver pathology may be due to AdoHcy-mediated inhibition of AdoMet-dependent transmethylation reactions.

Pubmed ID: 7670465 RIS Download

Mesh terms: Adenosine Deaminase | Animals | Animals, Newborn | Base Sequence | Cell Death | DNA Primers | Disease Models, Animal | Embryonic and Fetal Development | Female | Gene Targeting | Homozygote | Humans | Intestine, Small | Liver | Male | Methylation | Mice | Molecular Sequence Data | Mutation | Pregnancy | Pulmonary Atelectasis | Purines | Severe Combined Immunodeficiency | T-Lymphocyte Subsets

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Associated grants

  • Agency: NIDDK NIH HHS, Id: DK20902

Gene Ontology (Data, Gene Annotation)

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