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Requirement of MIP-1 alpha for an inflammatory response to viral infection.

Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.

Pubmed ID: 7667639


  • Cook DN
  • Beck MA
  • Coffman TM
  • Kirby SL
  • Sheridan JF
  • Pragnell IB
  • Smithies O


Science (New York, N.Y.)

Publication Data

September 15, 1995

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM20069
  • Agency: NHLBI NIH HHS, Id: HL37001
  • Agency: NHLBI NIH HHS, Id: R29HL46195

Mesh Terms

  • Animals
  • Antibodies, Viral
  • B-Lymphocytes
  • Base Sequence
  • Chemokine CCL4
  • Coxsackievirus Infections
  • Cytokines
  • Enterovirus B, Human
  • Gene Targeting
  • Hematopoiesis
  • Influenza A virus
  • Lymphocyte Activation
  • Macrophage Inflammatory Proteins
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Monokines
  • Myocarditis
  • Neutralization Tests
  • Orthomyxoviridae Infections
  • Stem Cells
  • T-Lymphocytes