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Requirement of MIP-1 alpha for an inflammatory response to viral infection.

Science (New York, N.Y.) | Sep 15, 1995

Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.

Pubmed ID: 7667639 RIS Download

Mesh terms: Animals | Antibodies, Viral | B-Lymphocytes | Base Sequence | Chemokine CCL4 | Coxsackievirus Infections | Cytokines | Enterovirus B, Human | Gene Targeting | Hematopoiesis | Influenza A virus | Lymphocyte Activation | Macrophage Inflammatory Proteins | Mice | Mice, Inbred C57BL | Molecular Sequence Data | Monokines | Myocarditis | Neutralization Tests | Orthomyxoviridae Infections | Stem Cells | T-Lymphocytes

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM20069
  • Agency: NHLBI NIH HHS, Id: HL37001
  • Agency: NHLBI NIH HHS, Id: R29HL46195

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