Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

Cell | Aug 25, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7664341

Mice lacking cyclin D1 have been generated by gene targeting in embryonic stem cells. Cyclin D1-deficient animals develop to term but show reduced body size, reduced viability, and symptoms of neurological impairment. Their retinas display a striking reduction in cell number due to proliferative failure during embryonic development. In situ hybridization studies of normal mouse embryos revealed an extremely high level of cyclin D1 in the retina, suggesting a special dependence of this tissue on cyclin D1. In adult mutant females, the breast epithelial compartment fails to undergo the massive proliferative changes associated with pregnancy despite normal levels of ovarian steroid hormones. Thus, steroid-induced proliferation of mammary epithelium during pregnancy may be driven through cyclin D1.

Pubmed ID: 7664341 RIS Download

Mesh terms: Animals | Cell Differentiation | Cell Division | Cyclin D1 | Cyclins | Female | Gene Expression Regulation, Developmental | Gene Targeting | Male | Mammary Glands, Animal | Mice | Mice, Mutant Strains | Neoplasms, Experimental | Oncogene Proteins | Phenotype | Pregnancy | Receptors, Estrogen | Retina | Stem Cells | Steroids

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.