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The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.

Cancer research | Sep 15, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7664264

Rak is a nuclear tyrosine kinase containing Src homology 2 and 3 domains at its NH2 terminus. We report here that the retinoblastoma tumor susceptibility gene product pRb associates with Rak in vivo and in vitro. Rak binds in the A/B pocket region of pRb, a region that is frequently mutated in human cancer, during the G1 and S phases of the cell cycle. Furthermore, Rak expression is elevated in G1, and transfection of Rak into NIH 3T3 cells results in a significant decrease in the number of emerging colonies. Thus, Rak is a tyrosine kinase with growth suppressing activity that may function, in part, through its interaction with pRb.

Pubmed ID: 7664264 RIS Download

Mesh terms: 3T3 Cells | Amino Acid Sequence | Animals | Humans | Mice | Molecular Sequence Data | Neoplasm Proteins | Phosphorylation | Protein-Tyrosine Kinases | Retinoblastoma Protein | Tumor Cells, Cultured | src-Family Kinases

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Associated grants

  • Agency: NCI NIH HHS, Id: CA01625
  • Agency: NCI NIH HHS, Id: CA58233-03

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