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The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.

Rak is a nuclear tyrosine kinase containing Src homology 2 and 3 domains at its NH2 terminus. We report here that the retinoblastoma tumor susceptibility gene product pRb associates with Rak in vivo and in vitro. Rak binds in the A/B pocket region of pRb, a region that is frequently mutated in human cancer, during the G1 and S phases of the cell cycle. Furthermore, Rak expression is elevated in G1, and transfection of Rak into NIH 3T3 cells results in a significant decrease in the number of emerging colonies. Thus, Rak is a tyrosine kinase with growth suppressing activity that may function, in part, through its interaction with pRb.

Pubmed ID: 7664264

Authors

  • Craven RJ
  • Cance WG
  • Liu ET

Journal

Cancer research

Publication Data

September 15, 1995

Associated Grants

  • Agency: NCI NIH HHS, Id: CA01625
  • Agency: NCI NIH HHS, Id: CA58233-03

Mesh Terms

  • 3T3 Cells
  • Amino Acid Sequence
  • Animals
  • Humans
  • Mice
  • Molecular Sequence Data
  • Neoplasm Proteins
  • Phosphorylation
  • Protein-Tyrosine Kinases
  • Retinoblastoma Protein
  • Tumor Cells, Cultured
  • src-Family Kinases