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p53 modulation of TFIIH-associated nucleotide excision repair activity.

p53 has pleiotropic functions including control of genomic plasticity and integrity. Here we report that p53 can bind to several transcription factor IIH-associated factors, including transcription-repair factors, XPD (Rad3) and XPB, as well as CSB involved in strand-specific DNA repair, via its C-terminal domain. We also found that wild-type, but not Arg273His mutant p53 inhibits XPD (Rad3) and XPB DNA helicase activities. Moreover, repair of UV-induced dimers is slower in Li-Fraumeni syndrome cells (heterozygote p53 mutant) than in normal human cells. Our findings indicate that p53 may play a direct role in modulating nucleotide excision repair pathways.

Pubmed ID: 7663514


  • Wang XW
  • Yeh H
  • Schaeffer L
  • Roy R
  • Moncollin V
  • Egly JM
  • Wang Z
  • Freidberg EC
  • Evans MK
  • Taffe BG


Nature genetics

Publication Data

June 12, 1995

Associated Grants


Mesh Terms

  • Adenosine Triphosphatases
  • Amino Acid Sequence
  • Chromosome Mapping
  • Cockayne Syndrome
  • DNA Helicases
  • DNA Repair
  • DNA Repair Enzymes
  • DNA-Binding Proteins
  • Enzyme Activation
  • Humans
  • Li-Fraumeni Syndrome
  • Models, Molecular
  • Molecular Sequence Data
  • Nucleotides
  • Protein Structure, Secondary
  • Proteins
  • Saccharomyces cerevisiae Proteins
  • Transcription Factor TFIIH
  • Transcription Factors
  • Transcription Factors, TFII
  • Tumor Cells, Cultured
  • Tumor Suppressor Protein p53
  • Xeroderma Pigmentosum
  • Xeroderma Pigmentosum Group D Protein