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Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II.

Science (New York, N.Y.) | Sep 8, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7660129

The Elongin (SIII) complex activates elongation by mammalian RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Here, the mammalian Elongin A gene was isolated and expressed, and the Elongin (SIII) complex reconstituted with recombinant subunits. Elongin A is shown to function as the transcriptionally active component of Elongin (SIII) and Elongin B and C as regulatory subunits. Whereas Elongin C assembles with Elongin A to form an AC complex with increased specific activity, Elongin B, a member of the ubiquitin-homology gene family, appears to serve a chaperone-like function, facilitating assembly and enhancing stability of the Elongin (SIII) complex.

Pubmed ID: 7660129 RIS Download

Mesh terms: Amino Acid Sequence | Base Sequence | Genes, Tumor Suppressor | Ligases | Molecular Sequence Data | Nuclear Proteins | RNA Polymerase II | RNA, Messenger | Recombinant Proteins | Temperature | Transcription Factors | Transcription, Genetic | Tumor Suppressor Proteins | Ubiquitin-Protein Ligases | Von Hippel-Lindau Tumor Suppressor Protein

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM41628

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