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Inducible gene targeting in mice.


A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an interferon-responsive promoter to control the expression of Cre recombinase. Here, Cre was used to delete a segment of the DNA polymerase beta gene flanked by IoxP recombinase recognition sites. Deletion was complete in liver and nearly complete in lymphocytes within a few days, whereas partial deletion was obtained in other tissues. This method can be used for the inducible inactivation of any other gene in vivo.

Pubmed ID: 7660125


  • Kühn R
  • Schwenk F
  • Aguet M
  • Rajewsky K


Science (New York, N.Y.)

Publication Data

September 8, 1995

Associated Grants


Mesh Terms

  • Animals
  • Crosses, Genetic
  • DNA Nucleotidyltransferases
  • DNA Polymerase I
  • Female
  • GTP-Binding Proteins
  • Gene Targeting
  • Genetic Vectors
  • Integrases
  • Interferon-alpha
  • Interferon-beta
  • Liver
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Mice, Transgenic
  • Myxovirus Resistance Proteins
  • Poly I-C
  • Promoter Regions, Genetic
  • Proteins
  • Recombination, Genetic
  • Sequence Deletion
  • Viral Proteins