• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Impaired energy homeostasis in C/EBP alpha knockout mice.

Mice homozygous for the targeted deletion of the c/ebp alpha gene, which expresses the CCAAT/enhancer-binding protein alpha (C/EBP alpha), did not store hepatic glycogen and died from hypoglycemia within 8 hours after birth. In these mutant mice, the amounts of glycogen synthase messenger RNA were 50 to 70 percent of normal and the transcriptional induction of the genes for two gluconeogenic enzymes, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, was delayed. The hepatocytes and adipocytes of the mutant mice failed to accumulate lipid and the expression of the gene for uncoupling protein, the defining marker of brown adipose tissue, was reduced. This study demonstrates that C/EBP alpha is critical for the establishment and maintenance of energy homeostasis in neonates.

Pubmed ID: 7652557

Authors

  • Wang ND
  • Finegold MJ
  • Bradley A
  • Ou CN
  • Abdelsayed SV
  • Wilde MD
  • Taylor LR
  • Wilson DR
  • Darlington GJ

Journal

Science (New York, N.Y.)

Publication Data

August 25, 1995

Associated Grants

  • Agency: NIDDK NIH HHS, Id: DK 45285

Mesh Terms

  • Adipose Tissue
  • Adipose Tissue, Brown
  • Animals
  • Animals, Newborn
  • Blood Glucose
  • CCAAT-Enhancer-Binding Proteins
  • Carrier Proteins
  • DNA-Binding Proteins
  • Energy Metabolism
  • Female
  • Gene Expression Regulation
  • Glucose-6-Phosphatase
  • Glycogen Synthase
  • Homeostasis
  • Humans
  • Ion Channels
  • Lipid Metabolism
  • Liver
  • Liver Glycogen
  • Male
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Mitochondrial Proteins
  • Nuclear Proteins
  • Phosphoenolpyruvate Carboxykinase (GTP)
  • RNA, Messenger
  • Serum Albumin