Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.

Genes & development | Aug 1, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7649470

The yeast Ste20 protein kinase is involved in pheromone response. Mammalian homologs of Ste20 exist, but their function remains unknown. We identified a novel yeast STE20 homolog, CLA4, in a screen for mutations lethal in the absence of the G1 cyclins Cln1 and Cln2. Cla4 is involved in budding and cytokinesis and interacts with Cdc42, a GTPase required for polarized cell growth. Despite a cytokinesis defect, cla4 mutants are viable. However, double cla4 ste20 mutants cannot maintain septin rings at the bud neck and cannot undergo cytokinesis. Mutations in CDC12, which encodes one of the septins, were found in the same screen. Cla4 and Ste20 kinases apparently share a function in localizing cell growth with respect to the septin ring.

Pubmed ID: 7649470 RIS Download

Mesh terms: Amino Acid Sequence | Cell Compartmentation | Cell Cycle Proteins | Cell Division | Cell Polarity | Cyclins | Fungal Proteins | GTP Phosphohydrolases | Genes, Fungal | Intracellular Signaling Peptides and Proteins | MAP Kinase Kinase Kinases | Molecular Sequence Data | Pheromones | Protein Kinase C | Protein-Serine-Threonine Kinases | Saccharomyces cerevisiae Proteins | Sequence Homology, Amino Acid | Signal Transduction | Yeasts

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIGMS NIH HHS, Id: GM 31006

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.