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Integration of MAP kinase signal transduction pathways at the serum response element.

Science (New York, N.Y.) | Jul 21, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7618106

The ternary complex factor (TCF) subfamily of ETS-domain transcription factors bind with serum response factor (SRF) to the serum response element (SRE) and mediate increased gene expression. The TCF protein Elk-1 is phosphorylated by the JNK and ERK groups of mitogen-activated protein (MAP) kinases causing increased DNA binding, ternary complex formation, and transcriptional activation. Activated SRE-dependent gene expression is induced by JNK in cells treated with interleukin-1 and by ERK after treatment with phorbol ester. The Elk-1 transcription factor therefore integrates MAP kinase signaling pathways in vivo to coordinate biological responses to different extracellular stimuli.

Pubmed ID: 7618106 RIS Download

Mesh terms: Animals | CHO Cells | Calcium-Calmodulin-Dependent Protein Kinases | Cricetinae | DNA-Binding Proteins | Gene Expression Regulation | Interleukin-1 | JNK Mitogen-Activated Protein Kinases | MAP Kinase Kinase 1 | Mitogen-Activated Protein Kinase 1 | Mitogen-Activated Protein Kinase 3 | Mitogen-Activated Protein Kinase Kinases | Mitogen-Activated Protein Kinases | Nuclear Proteins | Phosphorylation | Promoter Regions, Genetic | Protein-Serine-Threonine Kinases | Protein-Tyrosine Kinases | Proto-Oncogene Proteins | Serum Response Factor | Signal Transduction | Tetradecanoylphorbol Acetate | Transcription Factors | Transfection | ets-Domain Protein Elk-1 | ets-Domain Protein Elk-4