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Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.

Science (New York, N.Y.) | Jul 14, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7618084

Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.

Pubmed ID: 7618084 RIS Download

Mesh terms: Abnormalities, Multiple | Animals | Base Sequence | Brain | Cell Division | Digestive System | Digestive System Abnormalities | Embryonic and Fetal Development | Female | Gene Targeting | Hair | Homozygote | Kidney | Lung | Male | Mice | Molecular Sequence Data | Mutation | Phenotype | Receptor, Epidermal Growth Factor | Skin | Skin Abnormalities

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM14630
  • Agency: NICHD NIH HHS, Id: HD07104
  • Agency: NICHD NIH HHS, Id: HD26722

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