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Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.

Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.

Pubmed ID: 7618084

Authors

  • Threadgill DW
  • Dlugosz AA
  • Hansen LA
  • Tennenbaum T
  • Lichti U
  • Yee D
  • LaMantia C
  • Mourton T
  • Herrup K
  • Harris RC

Journal

Science (New York, N.Y.)

Publication Data

July 14, 1995

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM14630
  • Agency: NICHD NIH HHS, Id: HD07104
  • Agency: NICHD NIH HHS, Id: HD26722

Mesh Terms

  • Abnormalities, Multiple
  • Animals
  • Base Sequence
  • Brain
  • Cell Division
  • Digestive System
  • Digestive System Abnormalities
  • Embryonic and Fetal Development
  • Female
  • Gene Targeting
  • Hair
  • Homozygote
  • Kidney
  • Lung
  • Male
  • Mice
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • Receptor, Epidermal Growth Factor
  • Skin
  • Skin Abnormalities