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A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

Genes & development | Nov 15, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7590254

BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development.

Pubmed ID: 7590254 RIS Download

Mesh terms: Animals | Base Sequence | Bone Morphogenetic Protein 7 | Bone Morphogenetic Proteins | DNA Primers | Eye | Female | Kidney | Mice | Mice, Inbred C57BL | Molecular Sequence Data | Mutation | Proteins | Transforming Growth Factor beta

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Associated grants

  • Agency: PHS HHS, Id: R01-25208

Mouse Genome Informatics (Data, Gene Annotation)

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