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A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development.

Pubmed ID: 7590254


  • Dudley AT
  • Lyons KM
  • Robertson EJ


Genes & development

Publication Data

November 15, 1995

Associated Grants

  • Agency: PHS HHS, Id: R01-25208

Mesh Terms

  • Animals
  • Base Sequence
  • Bone Morphogenetic Protein 7
  • Bone Morphogenetic Proteins
  • DNA Primers
  • Eye
  • Female
  • Kidney
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Mutation
  • Proteins
  • Transforming Growth Factor beta