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Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.

Pubmed ID: 7566114


  • Hörlein AJ
  • Näär AM
  • Heinzel T
  • Torchia J
  • Gloss B
  • Kurokawa R
  • Ryan A
  • Kamei Y
  • Söderström M
  • Glass CK



Publication Data

October 5, 1995

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Cell Line
  • DNA
  • Gene Expression Regulation
  • Humans
  • Ligands
  • Mice
  • Molecular Sequence Data
  • Mutagenesis, Site-Directed
  • Nuclear Proteins
  • Nuclear Receptor Co-Repressor 1
  • Oligodeoxyribonucleotides
  • Protein Binding
  • Receptors, Retinoic Acid
  • Receptors, Thyroid Hormone
  • Recombinant Fusion Proteins
  • Repressor Proteins
  • Transcription, Genetic
  • Transfection
  • Tretinoin
  • Triiodothyronine