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Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.

Nature | Oct 5, 1995

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.

Pubmed ID: 7566114 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Base Sequence | Binding Sites | Cell Line | DNA | Gene Expression Regulation | Humans | Ligands | Mice | Molecular Sequence Data | Mutagenesis, Site-Directed | Nuclear Proteins | Nuclear Receptor Co-Repressor 1 | Oligodeoxyribonucleotides | Protein Binding | Receptors, Retinoic Acid | Receptors, Thyroid Hormone | Recombinant Fusion Proteins | Repressor Proteins | Transcription, Genetic | Transfection | Tretinoin | Triiodothyronine

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