We have delimited the extra sex combs (esc) gene to < 4 kb that include a single transcript and are able to rescue both the maternal and zygotic esc phenotypes. Several mutations have been identified within the esc transcript. In agreement with earlier genetic studies, esc is expressed maternally and its product is most abundant during the early embryonic stages. It encodes a protein of the WD-40 repeat family, which localizes predominantly to the nucleus. During germ band extension, it is expressed in a stereotypic pattern of neuroblasts. We propose a model in which Esc is recruited by gap proteins both to act as a corepressor that competes with the TAFII80 coactivator to block transcription and also to mediate the transition to permanent repression by Polycomb-group proteins.
Pubmed ID: 7556071 RIS Download
Mesh terms: Amino Acid Sequence | Animals | Animals, Genetically Modified | Base Sequence | Cell Nucleus | Drosophila | Drosophila Proteins | Embryo, Nonmammalian | Female | Genes, Insect | Histone-Lysine N-Methyltransferase | Insect Hormones | Male | Molecular Sequence Data | Multigene Family | Nervous System | Nervous System Physiological Phenomena | Nuclear Proteins | Polycomb Repressive Complex 1 | Polycomb Repressive Complex 2 | Protein Biosynthesis | Proteins | Restriction Mapping | Sequence Homology, Amino Acid | Zygote
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