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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.

The interleukin-1 beta (IL-1 beta) converting enzyme (ICE) processes the inactive IL-1 beta precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene (ICE-/-) did not export IL-1 beta or interleukin-1 alpha (IL-1 alpha) after stimulation with lipopolysaccharide. Export of tumor necrosis factor-alpha and interleukin-6 (IL-6) from these cells was also diminished. Thymocytes from ICE-/- mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptosis induced by Fas antibody. Despite this defect in apoptosis, ICE-/- mice proceed normally through development.

Pubmed ID: 7535475

Authors

  • Kuida K
  • Lippke JA
  • Ku G
  • Harding MW
  • Livingston DJ
  • Su MS
  • Flavell RA

Journal

Science (New York, N.Y.)

Publication Data

March 31, 1995

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Antigens, CD95
  • Antigens, Surface
  • Apoptosis
  • Base Sequence
  • Caspase 1
  • Cells, Cultured
  • Chimera
  • Cysteine Endopeptidases
  • Cytokines
  • Dexamethasone
  • Female
  • Interleukin-1
  • Lipopolysaccharides
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Monocytes
  • Nigericin
  • T-Lymphocytes