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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.

Science (New York, N.Y.) | Mar 31, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7535475

The interleukin-1 beta (IL-1 beta) converting enzyme (ICE) processes the inactive IL-1 beta precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene (ICE-/-) did not export IL-1 beta or interleukin-1 alpha (IL-1 alpha) after stimulation with lipopolysaccharide. Export of tumor necrosis factor-alpha and interleukin-6 (IL-6) from these cells was also diminished. Thymocytes from ICE-/- mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptosis induced by Fas antibody. Despite this defect in apoptosis, ICE-/- mice proceed normally through development.

Pubmed ID: 7535475 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Antibodies, Monoclonal | Antigens, CD95 | Antigens, Surface | Apoptosis | Base Sequence | Caspase 1 | Cells, Cultured | Chimera | Cysteine Endopeptidases | Cytokines | Dexamethasone | Female | Interleukin-1 | Lipopolysaccharides | Male | Mice | Mice, Inbred C57BL | Molecular Sequence Data | Monocytes | Nigericin | T-Lymphocytes

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