• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation.

Vascular cell adhesion molecule-1 (VCAM-1) is expressed on vascular endothelium in a variety of inflammatory conditions and mediates leukocyte recruitment from blood into tissues. In this study we report a novel role for VCAM-1 in the formation of the umbilical cord and placenta during development. The murine VCAM1 gene was disrupted by targeted homologous recombination, and a distinct phenotype was found in VCAM-1-deficient embryos. At 8.5 days of gestation, the allantois failed to fuse to the chorion, resulting in abnormal placental development and embryonic death within 1-3 days. In addition, a role for VCAM-1 in early placental formation after chorioallantoic fusion was observed. In a minority of VCAM-1-deficient embryos, the allantois was able to fuse with the chorion, but the allantoic mesoderm was abnormally distributed over the chorionic surface. A small number of VCAM-1-deficient embryos survived, presumably by circumventing the placentation defects. They became viable and fertile adult mice with lack of VCAM-1 expression, normal organs, and an elevated number of circulating blood mononuclear leukocytes.

Pubmed ID: 7530222


  • Gurtner GC
  • Davis V
  • Li H
  • McCoy MJ
  • Sharpe A
  • Cybulsky MI


Genes & development

Publication Data

January 1, 1995

Associated Grants

  • Agency: NHLBI NIH HHS, Id: HL 36028
  • Agency: NHLBI NIH HHS, Id: HL 45563

Mesh Terms

  • Allantois
  • Animals
  • Base Sequence
  • Cell Adhesion Molecules
  • Chorion
  • Female
  • Heart Defects, Congenital
  • Immunohistochemistry
  • Integrin alpha4
  • Integrins
  • Leukocyte Count
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Molecular Sequence Data
  • Placenta
  • Placentation
  • Pregnancy
  • Tissue Distribution
  • Umbilical Cord
  • Vascular Cell Adhesion Molecule-1