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Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.

http://www.ncbi.nlm.nih.gov/pubmed/7512720

Granulocyte-colony-stimulating factor (G-CSF) stimulates the proliferation and differentiation of cells of the neutrophil lineage by interaction with a specific receptor. Early signal transduction events following G-CSF receptor activation were studied. We detected tyrosine phosphorylation of both the G-CSF receptor and the protein tyrosine kinase JAK1 following G-CSF binding to the human G-CSF receptor. In vitro, the kinase activity of JAK1 was increased by G-CSF stimulation. Coimmunoprecipitation of JAK1 with the G-CSF receptor suggested a physical association which existed prior to G-CSF stimulation.

Pubmed ID: 7512720 RIS Download

Mesh terms: Animals | CHO Cells | Cell Division | Cricetinae | Humans | Janus Kinase 1 | Phosphorylation | Phosphotyrosine | Protein-Tyrosine Kinases | Receptors, Granulocyte Colony-Stimulating Factor | Signal Transduction | Time Factors | Transfection | Tyrosine