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A human telomeric protein.

Telomeres are multifunctional elements that shield chromosome ends from degradation and end-to-end fusions, prevent activation of DNA damage checkpoints, and modulate the maintenance of telomeric DNA by telomerase. A major protein component of human telomeres has been identified and cloned. This factor, TRF, contains one Myb-type DNA-binding repeat and an amino-terminal acidic domain. Immunofluorescent labeling shows that TRF specifically colocalizes with telomeric DNA in human interphase cells and is located at chromosome ends during metaphase. The presence of TRF along the telomeric TTAGGG repeat array demonstrates that human telomeres form a specialized nucleoprotein complex.

Pubmed ID: 7502076

Authors

  • Chong L
  • van Steensel B
  • Broccoli D
  • Erdjument-Bromage H
  • Hanish J
  • Tempst P
  • de Lange T

Journal

Science (New York, N.Y.)

Publication Data

December 8, 1995

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM49046
  • Agency: NCI NIH HHS, Id: P30 CA08748-29

Mesh Terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Nucleus
  • Cloning, Molecular
  • DNA-Binding Proteins
  • HeLa Cells
  • Humans
  • Interphase
  • Metaphase
  • Molecular Sequence Data
  • Molecular Weight
  • Repetitive Sequences, Nucleic Acid
  • Sequence Alignment
  • Telomere
  • Transfection