Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

A human telomeric protein.

Science (New York, N.Y.) | Dec 8, 1995

http://www.ncbi.nlm.nih.gov/pubmed/7502076

Telomeres are multifunctional elements that shield chromosome ends from degradation and end-to-end fusions, prevent activation of DNA damage checkpoints, and modulate the maintenance of telomeric DNA by telomerase. A major protein component of human telomeres has been identified and cloned. This factor, TRF, contains one Myb-type DNA-binding repeat and an amino-terminal acidic domain. Immunofluorescent labeling shows that TRF specifically colocalizes with telomeric DNA in human interphase cells and is located at chromosome ends during metaphase. The presence of TRF along the telomeric TTAGGG repeat array demonstrates that human telomeres form a specialized nucleoprotein complex.

Pubmed ID: 7502076 RIS Download

Mesh terms: Amino Acid Sequence | Base Sequence | Cell Nucleus | Cloning, Molecular | DNA-Binding Proteins | HeLa Cells | Humans | Interphase | Metaphase | Molecular Sequence Data | Molecular Weight | Repetitive Sequences, Nucleic Acid | Sequence Alignment | Telomere | Transfection

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.