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Defective lymphoid development in mice lacking Jak3.

The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors. Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is predominantly expressed in hematopoietic cells and is known to associate only with the common gamma (gamma c) chain of the interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 receptors. Homozygous mutant mice in which the Jak3 gene had been disrupted were generated by gene targeting. Jak3-deficient mice had profound reductions in thymocytes and severe B cell and T cell lymphopenia similar to severe combined immunodeficiency disease (SCID), and the residual T cells and B cells were functionally deficient. Thus, Jak3 plays a critical role in gamma c signaling and lymphoid development.

Pubmed ID: 7481769

Authors

  • Nosaka T
  • van Deursen JM
  • Tripp RA
  • Thierfelder WE
  • Witthuhn BA
  • McMickle AP
  • Doherty PC
  • Grosveld GC
  • Ihle JN

Journal

Science (New York, N.Y.)

Publication Data

November 3, 1995

Associated Grants

  • Agency: NHLBI NIH HHS, Id: P01 HL53749
  • Agency: NCI NIH HHS, Id: P30 CA21765
  • Agency: NIDDK NIH HHS, Id: R01 DK/HL42932

Mesh Terms

  • Aging
  • Animals
  • Antigens, CD
  • B-Lymphocytes
  • Chimera
  • Female
  • Gene Targeting
  • Interleukin-7
  • Janus Kinase 3
  • Lymphocyte Activation
  • Lymphocyte Count
  • Lymphocyte Subsets
  • Lymphoid Tissue
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Phenotype
  • Protein-Tyrosine Kinases
  • Receptors, Interleukin
  • Receptors, Interleukin-7
  • Signal Transduction
  • T-Lymphocytes