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Defective lymphoid development in mice lacking Jak3.

Science (New York, N.Y.) | Nov 3, 1995

The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors. Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is predominantly expressed in hematopoietic cells and is known to associate only with the common gamma (gamma c) chain of the interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 receptors. Homozygous mutant mice in which the Jak3 gene had been disrupted were generated by gene targeting. Jak3-deficient mice had profound reductions in thymocytes and severe B cell and T cell lymphopenia similar to severe combined immunodeficiency disease (SCID), and the residual T cells and B cells were functionally deficient. Thus, Jak3 plays a critical role in gamma c signaling and lymphoid development.

Pubmed ID: 7481769 RIS Download

Mesh terms: Aging | Animals | Antigens, CD | B-Lymphocytes | Chimera | Female | Gene Targeting | Interleukin-7 | Janus Kinase 3 | Lymphocyte Activation | Lymphocyte Count | Lymphocyte Subsets | Lymphoid Tissue | Male | Mice | Mice, Inbred C57BL | Phenotype | Protein-Tyrosine Kinases | Receptors, Interleukin | Receptors, Interleukin-7 | Signal Transduction | T-Lymphocytes