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Sequence and organization of the human mitochondrial genome.

Nature | Apr 9, 1981

http://www.ncbi.nlm.nih.gov/pubmed/7219534

The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.

Pubmed ID: 7219534 RIS Download

Mesh terms: Base Sequence | Biological Evolution | Codon | DNA Replication | DNA, Mitochondrial | Genes | Humans | Nucleic Acid Precursors | Peptide Chain Initiation, Translational | Peptide Chain Termination, Translational | RNA, Ribosomal | RNA, Transfer | Transcription, Genetic

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM-00124
  • Agency: NIGMS NIH HHS, Id: GM-21405
  • Agency: NIGMS NIH HHS, Id: GM-25962

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