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Sequence and organization of the human mitochondrial genome.

The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.

Pubmed ID: 7219534


  • Anderson S
  • Bankier AT
  • Barrell BG
  • de Bruijn MH
  • Coulson AR
  • Drouin J
  • Eperon IC
  • Nierlich DP
  • Roe BA
  • Sanger F
  • Schreier PH
  • Smith AJ
  • Staden R
  • Young IG



Publication Data

April 9, 1981

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM-00124
  • Agency: NIGMS NIH HHS, Id: GM-21405
  • Agency: NIGMS NIH HHS, Id: GM-25962

Mesh Terms

  • Base Sequence
  • Biological Evolution
  • Codon
  • DNA Replication
  • DNA, Mitochondrial
  • Genes
  • Humans
  • Nucleic Acid Precursors
  • Peptide Chain Initiation, Translational
  • Peptide Chain Termination, Translational
  • RNA, Ribosomal
  • RNA, Transfer
  • Transcription, Genetic