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Diabetes, a new mutation in the mouse.

Science (New York, N.Y.) | Sep 2, 1966

http://www.ncbi.nlm.nih.gov/pubmed/5918576

Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans suggest neogenesis to compensate for insulin depletion.

Pubmed ID: 5918576 RIS Download

Mesh terms: Animals | Blood Glucose | Body Weight | Diabetes Mellitus | Female | Male | Mice | Mutation

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