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Excitatory and inhibitory interactions in localized populations of model neurons.

Coupled nonlinear differential equations are derived for the dynamics of spatially localized populations containing both excitatory and inhibitory model neurons. Phase plane methods and numerical solutions are then used to investigate population responses to various types of stimuli. The results obtained show simple and multiple hysteresis phenomena and limit cycle activity. The latter is particularly interesting since the frequency of the limit cycle oscillation is found to be a monotonic function of stimulus intensity. Finally, it is proved that the existence of limit cycle dynamics in response to one class of stimuli implies the existence of multiple stable states and hysteresis in response to a different class of stimuli. The relation between these findings and a number of experiments is discussed.

Pubmed ID: 4332108


  • Wilson HR
  • Cowan JD


Biophysical journal

Publication Data

January 9, 1972

Associated Grants


Mesh Terms

  • Evoked Potentials
  • Feedback
  • Models, Neurological
  • Neural Inhibition
  • Neurons
  • Periodicity
  • Synaptic Transmission