We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.
Pubmed ID: 3754034 RIS Download
Mesh terms: Amino Acid Sequence | Base Sequence | Cloning, Molecular | DNA | Female | Gene Expression Regulation | HeLa Cells | Humans | Oncogenes | Protein Conformation | RNA Caps | Receptors, Estrogen | Sequence Homology, Nucleic Acid | Solubility
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