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Reactive oxygen species (ROS), despite having damaging roles, serve as signaling molecules regulating diverse biological and physiological processes. Employing in vivo genetic studies in Drosophila, we show that besides causing G1-S arrest by activation of Dacapo, ROS can simultaneously inhibit cell growth by regulating the expression of 4EBP and S6K. This is achieved by triggering a signaling cascade that includes Ask1, JNK, and FOXO independent of the Tsc-TOR growth regulatory pathway. Qualitative and quantitative differences in the types of ROS molecules generated dictate whether cells undergo G1-S arrest only or experience blocks in both cell proliferation and growth. Importantly, during normal development, this signaling cascade is triggered by ecdysone in late larval fat body cells to restrict their growth prior to pupation by antagonizing insulin signaling. The present work reveals an unexpected role of ROS in systemic control of growth in response to steroid hormone signaling to establish organismal size.
Pubmed ID: 31063760 RIS Download
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This unknown targets Hoechst 33342
View all literature mentionsThis monoclonal targets Mouse Drosophila elav protein
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View all literature mentionsThis monoclonal targets 4E-BP1, phospho (Thr37 / Thr46)
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View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Rabbit IgG
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Mouse IgG
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis monoclonal targets Dacapo
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View all literature mentionsThis monoclonal targets Mouse Drosophila Cut protein product
View all literature mentionsThis monoclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis monoclonal targets & x03B2;-Galactosidase
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View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsDrosophila melanogaster with name y[d2] w[1118] P{ry[+t7.2]=ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{ry[+t7.2]=neoFRT}80B from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{w[+mC]=UAS-bsk.DN}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; Kr[If-1]/CyO; P{w[+mW.hs]=GAL4-da.G32}UH1 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=ppl-GAL4.P}2 from BDSC.
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View all literature mentionsDrosophila melanogaster with name Oregon-R-C from BDSC.
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=PZ}Thor[06270] cn[1]/CyO; ry[506] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=GAL4-ninaE.GMR}12/CyO; P{w[+mC]=UAS-InR.A1325D}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=Lsp2-GAL4.H}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{KK107907}VIE-260B from Flybase.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-Fra.Fbz}5 from BDSC.
View all literature mentionsStatistical analysis and scientific graphing software for Windows OS.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00793}attP2 from BDSC.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS01555}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-S6k.TE}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=tubP-GAL80[ts]}10; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-hid.Z}2/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-GFP.nls}8 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=UAS-Pi3K92E.Exel}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=UAS-Pi3K92E.A2860C}1 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=UAS-InR.K1409A}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-EcR.B1-DeltaC655.W650A}TP1-9 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00464}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+m*]=GAL4-ey.H}4-8/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00254}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*] hep[r75]/FM7c from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; foxo[Delta94]/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[118]; P{w[+mC]=tGPH}2; Sb[1]/TM3, Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[d2] w[1118] P{ry[+t7.2]=ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{w[+mC]=lacW}ND-PDSW[k10101] P{ry[+t7.2]=neoFRT}40A/CyO y[+] from DGGR.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=lacW}Thor[k13517] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00853}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; ry[506] P{y[+mDint2] w[BR.E.BR]=SUPor-P}SNF4Agamma[KG00325]/TM3, Sb[1] Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF03271}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.HM05104}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=r4-GAL4}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1]; P{w[+mC]=UAS-Cat.A}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=hsFLP}12, y[1] w[*]; sna[Sco]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1]; P{w[+mC]=UAS-Sod2.M}UM83 from BDSC.
View all literature mentionsDrosophila melanogaster with name ND-ACP[1303] vn[1] st[1]/TM6B, Tb[1] from BDSC.
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View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.HM05206}attP2 from BDSC.
View all literature mentionsThis monoclonal targets BrdU
View all literature mentionsDrosophila melanogaster with name w[*]; Kr[If-1]/CyO; P{w[+mW.hs]=GAL4-da.G32}UH1 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{KK107907}VIE-260B from Flybase.
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View all literature mentionsDrosophila melanogaster with name Oregon-R-C from BDSC.
View all literature mentionsStatistical analysis and scientific graphing software for Windows OS.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00793}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS01555}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-GFP.nls}8 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=tubP-GAL80[ts]}10; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-S6k.TE}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-hid.Z}2/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=UAS-InR.K1409A}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=UAS-Pi3K92E.A2860C}1 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=UAS-Pi3K92E.Exel}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=ppl-GAL4.P}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=Lsp2-GAL4.H}3 from BDSC.
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View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00254}attP2 from BDSC.
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View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+m*]=GAL4-ey.H}4-8/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-Fra.Fbz}5 from BDSC.
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View all literature mentionsDrosophila melanogaster with name w[*] hep[r75]/FM7c from BDSC.
View all literature mentionsDrosophila melanogaster with name w[118]; P{w[+mC]=tGPH}2; Sb[1]/TM3, Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=PZ}Thor[06270] cn[1]/CyO; ry[506] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{w[+mC]=UAS-bsk.DN}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=lacW}Thor[k13517] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[d2] w[1118] P{ry[+t7.2]=ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{w[+mC]=lacW}ND-PDSW[k10101] P{ry[+t7.2]=neoFRT}40A/CyO y[+] from DGGR.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.HM05104}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00853}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF03271}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; ry[506] P{y[+mDint2] w[BR.E.BR]=SUPor-P}SNF4Agamma[KG00325]/TM3, Sb[1] Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1]; P{w[+mC]=UAS-Sod2.M}UM83 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1]; P{w[+mC]=UAS-Cat.A}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=r4-GAL4}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=hsFLP}12, y[1] w[*]; sna[Sco]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; Kr[If-1]/CyO; P{w[+mW.hs]=GAL4-da.G32}UH1 from BDSC.
View all literature mentionsDrosophila melanogaster with name ND-ACP[1303] vn[1] st[1]/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[d2] w[1118] P{ry[+t7.2]=ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; RpS17[4] P{w[+m*] ry[+t7.2]=white-un1}70C P{ry[+t7.2]=neoFRT}80B/TM6B, P{y[+t7.7] ry[+t7.2]=Car20y}TPN1, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[d2] w[1118] P{ry[+t7.2]=ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{ry[+t7.2]=neoFRT}80B from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; wg[Sp-1]/CyO; P{w[+mC]=UAS-GFP.dsRNA.R}142 from BDSC.
View all literature mentionsDrosophila melanogaster with name Oregon-R-C from BDSC.
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets
View all literature mentionsDrosophila melanogaster with name P{KK107907}VIE-260B from Flybase.
View all literature mentionsThis unknown targets Hoechst 33342
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Rabbit IgG
View all literature mentionsThis polyclonal targets Mouse IgG
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.HM05206}attP2 from BDSC.
View all literature mentionsThis monoclonal targets synthetic phosphopeptide corresponding to residues surrounding Thr183/Tyr185 of human SAPK/JNK
View all literature mentionsThis polyclonal targets Drosophila p70 S6 Kinase, phospho (Thr398)
View all literature mentionsThis monoclonal targets alpha-Tubulin
View all literature mentionsThis monoclonal targets 4E-BP1, phospho (Thr37 / Thr46)
View all literature mentionsThis monoclonal targets Actin
View all literature mentionsThis polyclonal targets Lipoic Acid antibody
View all literature mentionsThis polyclonal targets Phospho-Drosophila Akt (Ser505)
View all literature mentionsThis monoclonal targets Dacapo
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=GAL4-ninaE.GMR}12/CyO; P{w[+mC]=UAS-InR.A1325D}3 from BDSC.
View all literature mentionsThis monoclonal targets futsch
View all literature mentionsThis monoclonal targets Mouse Drosophila Cut protein product
View all literature mentionsThis unknown targets Cleaved Dcp-1 (Asp216)
View all literature mentionsThis monoclonal targets Mouse Drosophila elav protein
View all literature mentionsThis monoclonal targets & x03B2;-Galactosidase
View all literature mentionsThis monoclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis monoclonal targets Discs large (Drosophila)
View all literature mentionsThis monoclonal targets BrdU
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