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Glioblastoma multiforme (GBM) undergoes metabolic reprogramming to meet the high ATP and anabolic demands of the tumor cells. However, the role of fatty acid oxidation (FAO) and its regulators in the GBM context has been largely unknown. Here, we show that the neural stem cell pro-proliferative factor acyl-CoA-binding protein (ACBP, also known as DBI) is highly expressed in GBM, and by binding to acyl-CoAs, it cell-autonomously maintains high proliferation rates, promoting tumor growth and poor survival in several preclinical models. Mechanistic experiments using ACBP-acyl-CoA binding affinity variants and pharmacological FAO modulators suggest that ACBP supports tumor growth by controlling the availability of long-chain fatty acyl-CoAs to mitochondria, promoting FAO in GBM. Thus, our findings uncover a critical link between lipid metabolism and GBM progression established by ACBP and offer a potential therapeutic strategy for an effective anti-proliferative metabolic management of GBM.
Pubmed ID: 31056285 RIS Download
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This polyclonal targets mouse DBI, 1-87 aa (NP031856)
View all literature mentionsThis polyclonal targets GFP
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View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgY (IgG) (H+L)
View all literature mentionsCell line OAT1 HEK 293T/17 is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NCH644 is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsCell line NCH421k is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsCell line U-87MG ATCC is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line LN-229 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line UMNSAH/DF-1 is a Spontaneously immortalized cell line with a species of origin Gallus gallus
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
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