Activation of axonal dopamine D2 receptors (D2Rs) increases action potential (AP) threshold, and thus decreases neuronal excitability in layer II stellate cells of medial entorhinal cortex. Endogenous dopamine release increases the AP threshold of stellate cells by activating D2Rs. Activation of D2Rs shifts the activation curve of T-type Ca2+ channels in a positive direction in a protein kinase A-dependent manner. Immunofluorescence staining reveals the presence of T-type Ca2+ channels and D2Rs in the axon initial segments (AISs). This research makes the pioneering discovery of D2R-induced AP threshold plasticity in AISs of stellate cells. The findings are likely to have significant implications for understanding the cellular processes by which dopamine influences neuronal intrinsic excitability.
Pubmed ID: 31049961 RIS Download
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