This study demonstrates glial and gliovascular markers of organon vasculosum laminae terminalis (OVLT) in three planes. The distribution of glial markers displayed similarities to the subfornical organ. There was an inner part with vimentin- and nestin-immunopositive glia whereas GFAP and the water-channel aquaporin 4 were found at the periphery. This separation indicates different functions of the two regions. The presence of nestin may indicate stem cell-capabilities whereas aquaporin 4 has been reported to promote the osmoreceptor function. Glutamine synthetase immunoreactivity was sparse like in the area postrema and subfornical organ. The laminin and β-dystroglycan immunolabelings altered along the vessels such as in the subfornical organ indicating altering gliovascular relations. The different subdivisions of OVLT received glial processes of different origins. The posterior periventricular zone contained short vimentin-immunopositive processes from the ependyma of the adjacent surface of the third ventricle. The lateral periventricular zone received forceps-like process systems from the anterolateral part of the third ventricle. Most interestingly, the "dorsal cap" received a mixed group of long GFAP- and vimentin-immunopositive processes from a distant part of the third ventricle. The processes may have two functions: a guidance for newly produced cells like radial glia in immature brain and/or a connection between distant parts of the third ventricle and OVLT.
Pubmed ID: 31045238 RIS Download
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This monoclonal targets Glutamine Synthetase
View all literature mentionsThis monoclonal targets Synthetic peptide containing 15 of the last 16 amino acids at the extreme C-terminus of the human beta-dystroglycan sequence (PKNMTPYRSPPPYVP-PCOOH).
View all literature mentionsThis polyclonal targets Vimentin
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets Glial Fibrillary Acidic Protein
View all literature mentionsThis monoclonal targets Nestin
View all literature mentionsThis polyclonal targets Laminin antibody produced in rabbit
View all literature mentionsThis unknown targets Water Channel Aquaporin 4
View all literature mentionsThis polyclonal targets GFAP
View all literature mentionsThis unknown targets Chicken IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsThis unknown targets Water Channel Aquaporin 4
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsThis unknown targets Water Channel Aquaporin 4
View all literature mentionsThis polyclonal targets Vimentin
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Chicken IgG (H+L)
View all literature mentionsThis polyclonal targets Laminin antibody produced in rabbit
View all literature mentionsThis monoclonal targets Nestin
View all literature mentionsThis monoclonal targets Glial Fibrillary Acidic Protein
View all literature mentionsThis monoclonal targets Glutamine Synthetase
View all literature mentionsThis polyclonal targets GFAP
View all literature mentionsThis monoclonal targets Synthetic peptide containing 15 of the last 16 amino acids at the extreme C-terminus of the human beta-dystroglycan sequence (PKNMTPYRSPPPYVP-PCOOH).
View all literature mentions