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Publication

Sustained NPY signaling enables AgRP neurons to drive feeding.

eLife | 2019

Artificial stimulation of Agouti-Related Peptide (AgRP) neurons promotes intense food consumption, yet paradoxically during natural behavior these cells are inhibited before feeding begins. Previously, to reconcile these observations, we showed that brief stimulation of AgRP neurons can generate hunger that persists for tens of minutes, but the mechanisms underlying this sustained hunger drive remain unknown (Chen et al., 2016). Here we show that Neuropeptide Y (NPY) is uniquely required for the long-lasting effects of AgRP neurons on feeding behavior. We blocked the ability of AgRP neurons to signal through AgRP, NPY, or GABA, and then stimulated these cells using a paradigm that mimics their natural regulation. Deletion of NPY, but not AgRP or GABA, abolished optically-stimulated feeding, and this was rescued by NPY re-expression selectively in AgRP neurons. These findings reveal a unique role for NPY in sustaining hunger in the interval between food discovery and consumption.

Pubmed ID: 31033437 RIS Download

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Associated grants

Agency: American Diabetes Association, International
Id: ADA Accelerator Grant
Agency: NIH HHS, United States
Id: R01DK106399
Agency: NINDS NIH HHS, United States
Id: R01 NS094781
Agency: Howard Hughes Medical Institute, United States
Id: International Student Fellowship
Agency: NIDDK NIH HHS, United States
Id: R01 DK106399
Agency: NIDDK NIH HHS, United States
Id: DP2 DK109533
Agency: NIH HHS, United States
Id: 1DP2DK109533
Agency: NIH HHS, United States
Id: R01NS094781
Agency: NIH HHS, United States
Id: 5P30DK098722
Agency: National Institute of Diabetes & Digestive & Kidney Diseases, International
Id: 1F32DK118843

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MATLAB (tool)

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Multi paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.

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GraphPad Prism (tool)

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Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

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