Searching across hundreds of databases
Polyploid cells endoreplicate their DNA through a modified cell cycle that skips mitosis as part of their differentiation programs. Upon cell-cycle exit and differentiation, non-centrosomal sites govern microtubule distribution in most cells. Little is known on how polyploid cells, differentiated but cycling, organize their microtubules. We show that microtubules in Drosophila adipocytes and other polyploid tissues form a dense perinuclear cortex responsible for nuclear size and position. Confirming a relation between this perinuclear cortex and the polyploid endocycle, polyploidization of normally diploid cells was sufficient for cortex formation. A critical component of the perinuclear microtubule organizer (pnMTOC) is Shot, absence of which caused collapse of the perinuclear network into a condensed organizer through kinesin-dependent microtubule sliding. Furthermore, this ectopic organizer was capable of directing partial assembly of a deeply disruptive cytokinesis furrow. In all, our study revealed the importance of perinuclear microtubule organization for stability of endocycling Drosophila cells.
Pubmed ID: 31006649 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Imaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsVector graphics software to create digital graphics, illustrations, and typography for several types of media: print, web, interactive, video, and mobile.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsSoftware application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
View all literature mentionsThis polyclonal targets alphaTub84D
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets Lamin C
View all literature mentionsThis monoclonal targets klarsicht, exon 18
View all literature mentionsThis monoclonal targets Mouse Drosophila Shot
View all literature mentionsThis monoclonal targets gamma-Tubulin antibody produced in mouse
View all literature mentionsThis polyclonal targets Phospho-Histone H3 pSer10
View all literature mentionsDrosophila melanogaster with name PBac{fTRG00681.sfGFP-TVPTBF}VK00033 from Flybase.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS02488}attP2/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-Dcr-2.D}10 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=Cg-GAL4.A}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mW.hs]=GawB}pnr[MD237]/TM3, P{w[+mC]=UAS-y.C}MC2, Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-GFP.KDEL}15.2/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF02812}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF01373}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF02718}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*] P{w[+mC]=PTT-un1}ZCL1700 from DGGR.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-mito-HA-GFP.AP}2/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS01417}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name PBac{fTRG00638.sfGFP-TVPTBF}VK00033 from Flybase.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.GL01269}attP2/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00147}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name PBac{fTRG00574.sfGFP-TVPTBF}VK00033 from Flybase.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF02971}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.GL01286}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=tubP-GAL80[ts]}2/TM2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF01722}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mW.hs]=GawB}rn[GAL4-5]/TM3, P{ry[+t7.2]=ftz-lacC}SC1, ry[RK] Sb[1] Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-myr-mRFP}1 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{GD956}v21594/TM3 from Flybase.
View all literature mentionsDrosophila melanogaster with name P{KK111668}VIE-260B from Flybase.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UASp-mRFP-scra}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Grasp65-GFP}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Rab11-GFP}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Rab7.GFP}3 from BDSC.
View all literature mentionsThis is a legacy resource.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00506}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{y[+mDint2]=MIC}shot[MI14321] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS02598}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UASp-GFPS65C-alphaTub84B}3/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=UASp-GFPS65C-alphaTub84B}14-6-II/CyO, P{ry[+t7.2]=sevRas1.V12}FK1 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-shot.L(C)-GFP}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=PTT-GB}koi[CB04483] from BDSC.
View all literature mentionsThis is a legacy resource.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00368}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+m*]=alphaTub-Khc.GFP}R from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF02979}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.GL01316}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{y[+mDint2]=MIC}Msp300[MI02921] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=Ubi-p63E-Patronin.A.GFP}3M/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00510}attP2 from BDSC.
View all literature mentionsThis is a legacy resource.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=Ubi-p63E-Patronin.A.GFP}1M/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS01543}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF03004}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF02473}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UASp-GFP-Cnn1}26-1, w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.JF02838}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.HM05027}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00375}attP2/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=UASp-GFP.Rho1}6 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS00437}attP2 from BDSC.
View all literature mentionsDiscontinued
View all literature mentionsDrosophila melanogaster with name gammaTub23C[A15-2] cn[1] bw[1]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; GM130[Delta23]; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=PTT-un1}G00454 from DGGR.
View all literature mentionsThis polyclonal targets alphaTub84D
View all literature mentionsDrosophila melanogaster with name PBac{fTRG00638.sfGFP-TVPTBF}VK00033 from Flybase.
View all literature mentionsDrosophila melanogaster with name PBac{fTRG00681.sfGFP-TVPTBF}VK00033 from Flybase.
View all literature mentionsDrosophila melanogaster with name PBac{fTRG00574.sfGFP-TVPTBF}VK00033 from Flybase.
View all literature mentionsDrosophila melanogaster with name w[*] P{w[+mC]=PTT-un1}ZCL1700 from DGGR.
View all literature mentionsDrosophila melanogaster with name P{KK111668}VIE-260B from Flybase.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{GD956}v21594/TM3 from Flybase.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
