Contrary to the classic model of protein kinase A (PKA) residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this complex; however, when cAMP is generated at the plasma membrane, PDE4 serves as a local sink and PDE3 as a barrier to prevent accumulation of cAMP within the microdomain as a means of controlling activation of tethered nuclear PKA.
Pubmed ID: 30982750 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This polyclonal targets PDE3B (H-300)
View all literature mentionsThis unknown targets Protein A/G PLUS-Agarose
View all literature mentionsThis polyclonal targets Beta-Tubulin
View all literature mentionsThis polyclonal targets AKAP 95 (R-146)
View all literature mentionsThis monoclonal targets PKA IIalpha reg (H-12)
View all literature mentionsThis monoclonal targets PRKACA
View all literature mentionsThis monoclonal targets CREB
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets PRKAR2A
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentions