Adult-onset hearing loss is very common, but we know little about the underlying molecular pathogenesis impeding the development of therapies. We took a genetic approach to identify new molecules involved in hearing loss by screening a large cohort of newly generated mouse mutants using a sensitive electrophysiological test, the auditory brainstem response (ABR). We review here the findings from this screen. Thirty-eight unexpected genes associated with raised thresholds were detected from our unbiased sample of 1,211 genes tested, suggesting extreme genetic heterogeneity. A wide range of auditory pathophysiologies was found, and some mutant lines showed normal development followed by deterioration of responses, revealing new molecular pathways involved in progressive hearing loss. Several of the genes were associated with the range of hearing thresholds in the human population and one, SPNS2, was involved in childhood deafness. The new pathways required for maintenance of hearing discovered by this screen present new therapeutic opportunities.
Pubmed ID: 30973865 RIS Download
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Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsDigital image processing system where microscope settings and processing steps may be adjusted in single user interface. Can acquire images from variety of cameras. Includes software package for capturing, archiving and preparing images for publication. Allows users to visualize and present images in several dimensions. Functionality of imaging toolbox expands constantly with wide range of different modules that are tailored to specific applications or microscope accessories. This resource is duplicated by SCR_018376
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View all literature mentionsA commercial antibody supplier which supplies primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits.
View all literature mentionslaboratory mouse with name 129S5/SvEvBrdWtsi from MGI.
View all literature mentionslaboratory mouse with name C57BL/6N from MGI.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
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View all literature mentionsThis monoclonal targets Vinculin antibody [EPR8185]
View all literature mentionsThis monoclonal targets LIS1 antibody [EPR3335(2)]
View all literature mentionsThis polyclonal targets 14-3-3 epsilon (T-16)
View all literature mentionsThis monoclonal targets Vinculin antibody [EPR8185]
View all literature mentionsThis polyclonal targets 14-3-3 epsilon (T-16)
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis monoclonal targets Vinculin antibody [EPR8185]
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis monoclonal targets LIS1 antibody [EPR3335(2)]
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