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The brain, spinal cord, and retina are supplied by capillaries that do not permit free diffusion of molecules between serum and parenchyma, a property that defines the blood-brain and blood-retina barriers. Exceptions to this pattern are found in circumventricular organs (CVOs), small midline brain structures that are supplied by high permeability capillaries. In the eye and brain, high permeability capillaries are also present in the choriocapillaris, which supplies the retinal pigment epithelium and photoreceptors, and the ciliary body and choroid plexus, the sources of aqueous humor and cerebrospinal fluid, respectively. We show here that (1) endothelial cells in these high permeability vascular systems have very low beta-catenin signaling compared to barrier-competent endothelial cells, and (2) elevating beta-catenin signaling leads to a partial conversion of permeable endothelial cells to a barrier-type state. In one CVO, the area postrema, high permeability is maintained, in part, by local production of Wnt inhibitory factor-1.
Pubmed ID: 30932813 RIS Download
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A contract research organization providing drug development and animal testing services. Under the name Covance Research Products Inc., based in Denver, Pennsylvania, the company also deals in the import, breeding and sale of laboratory animals. It breeds dogs, rabbits, guinea pigs, non-human primates, and pigs, and runs the largest non-human primate laboratory in Germany. (Wikipedia)
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View all literature mentionsThis unknown targets Biotin
View all literature mentionsA powerful toolset for genome arithmetic allowing one to address common genomics tasks such as finding feature overlaps and computing coverage. Bedtools allows one to intersect, merge, count, complement, and shuffle genomic intervals from multiple files in widely-used genomic file formats such as BAM, BED, GFF/GTF, VCF. While each individual tool is designed to do a relatively simple task (e.g., intersect two interval files), quite sophisticated analyses can be conducted by combining multiple bedtools operations on the UNIX command line.
View all literature mentionsCompute differentially bound sites from multiple ChIP-seq experiments using affinity (quantitative) data. Also enables occupancy (overlap) analysis and plotting functions.
View all literature mentionsSoftware R package for RNA-Seq Differential Expression Analysis.
View all literature mentionsSoftware R package for importing pseudoaligned reads into R for use with downstream differential expression analysis. Used for import and summarize transcript level estimates for transcript and gene level analysis.
View all literature mentionsPython based tools to process, visualize and analyse high-throughput sequencing data, such as ChIP-seq, RNA-seq or MNase-seq. Implemented within Galaxy framework. Used to perform complete bioinformatic workflows ranging from quality controls and normalizations of aligned reads to integrative analyses, including clustering and visualization approaches.
View all literature mentionsSoftware tool for quantifying abundances of transcripts from RNA-Seq data or target sequences using high-throughput sequencing reads.
View all literature mentionsThis polyclonal targets Vimentin
View all literature mentionsThis polyclonal targets ZO-1
View all literature mentionsThis unknown targets Occludin
View all literature mentionsThis monoclonal targets LEF1 (C12A5) Rabbit mAb
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis monoclonal targets Claudin 5
View all literature mentionsThis monoclonal targets Panendothelial Cell Antigen
View all literature mentionsThis polyclonal targets GLUT-1
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View all literature mentionsThis polyclonal targets Vimentin
View all literature mentionsThis polyclonal targets Vimentin
View all literature mentionsMus musculus with name B6;129-Fzd4tm2.1Nat/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(TIE2GFP)287Sato/J from IMSR.
View all literature mentionsMus musculus with name B6;129-Gt(ROSA)26Sortm11(CAG-tdTomato*.-GFP*)Nat/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Tg(Tek-cre)1Ywa/J from IMSR.
View all literature mentionsMus musculus with name B6J.129(Cg)-Rpl22tm1.1Psam/SjJ from IMSR.
View all literature mentionsThis polyclonal targets Vimentin
View all literature mentionsMus musculus with name B6;129-Fzd4tm1Nat/J from IMSR.
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