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Skin conventional dendritic cells (cDCs) exist as two distinct subsets, cDC1s and cDC2s, which maintain the balance of immunity to pathogens and tolerance to self and microbiota. Here, we examined the roles of dermal cDC1s and cDC2s during bacterial infection, notably Propionibacterium acnes (P. acnes). cDC1s, but not cDC2s, regulated the magnitude of the immune response to P. acnes in the murine dermis by controlling neutrophil recruitment to the inflamed site and survival and function therein. Single-cell mRNA sequencing revealed that this regulation relied on secretion of the cytokine vascular endothelial growth factor α (VEGF-α) by a minor subset of activated EpCAM+CD59+Ly-6D+ cDC1s. Neutrophil recruitment by dermal cDC1s was also observed during S. aureus, bacillus Calmette-Guérin (BCG), or E. coli infection, as well as in a model of bacterial insult in human skin. Thus, skin cDC1s are essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.
Pubmed ID: 30926233 RIS Download
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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsThis polyclonal targets Histone H3 (citrulline 2 + 8 + 17) antibody - ChIP Grade
View all literature mentionsThis polyclonal targets Mouse VEGF R1 / Flt-1
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD326
View all literature mentionsThis unknown targets Streptavidin-BD Horizon(tm) PE-CF594
View all literature mentionsThis monoclonal targets CD59a
View all literature mentionsThis monoclonal targets CD141
View all literature mentionsThis monoclonal targets beta Actin
View all literature mentionsThis monoclonal targets CD64
View all literature mentionsThis monoclonal targets Ly-6D
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD20
View all literature mentionsThis monoclonal targets CD56
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD326
View all literature mentionsThis monoclonal targets CD16
View all literature mentionsThis monoclonal targets HLA-DR
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD1c
View all literature mentionsThis monoclonal targets CD24
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets Fc epsilon RI alpha
View all literature mentionsThis monoclonal targets CD14
View all literature mentionsThis monoclonal targets CD370 (CLEC9A)
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View all literature mentionsThis monoclonal targets VEGF antibody [EP1176Y] - Carboxyterminal end
View all literature mentionsThis monoclonal targets CD317 (BST2, PDCA-1)
View all literature mentionsThis monoclonal targets CD66b
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View all literature mentionsThis monoclonal targets CD182
View all literature mentionsThis monoclonal targets I-A/I-E
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets Human VEGF R1 / Flt-1
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis polyclonal targets Mouse Mer
View all literature mentionsThis polyclonal targets Mouse VEGF R1 / Flt-1
View all literature mentionsThis monoclonal targets Ly-6G and Ly-6C
View all literature mentionsThis monoclonal targets Siglec H
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View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets Mouse IL-17 R MAb (Clone 657603)
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View all literature mentionsThis monoclonal targets FceR1 alpha
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View all literature mentionsThis monoclonal targets Mouse F4/80 ANTIGEN
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View all literature mentionsThis monoclonal targets CD90.2
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View all literature mentionsThis monoclonal targets CD86 (B7-2)
View all literature mentionsThis monoclonal targets Mouse thymus or spleen
View all literature mentionsThis monoclonal targets CD49d (Integrin alpha 4)
View all literature mentionsThis monoclonal targets CD49b
View all literature mentionsThis monoclonal targets CD48
View all literature mentionsThis monoclonal targets CD49b
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD64
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD317 (BST2, PDCA-1)
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD24
View all literature mentionsThis monoclonal targets CD43
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD195
View all literature mentionsThis monoclonal targets CD184 (CXCR4)
View all literature mentionsThis monoclonal targets CD191
View all literature mentionsThis monoclonal targets CD24
View all literature mentionsThis monoclonal targets CD127
View all literature mentionsThis monoclonal targets CD103
View all literature mentionsThis monoclonal targets CD120a
View all literature mentionsThis monoclonal targets CD309
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets Allophycocyanin
View all literature mentionsThis monoclonal targets CD172a
View all literature mentionsThis monoclonal targets Mouse IL-1 R4 / ST2L
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD274 (B7-H1, PD-L1)
View all literature mentionsThis monoclonal targets CD301
View all literature mentionsThis monoclonal targets CD134
View all literature mentionsThis monoclonal targets Allophycocyanin
View all literature mentionsThis monoclonal targets MHC class II (I-A)
View all literature mentionsThis monoclonal targets B220
View all literature mentionsThis monoclonal targets LFA-1α (CD11a)
View all literature mentionsThis monoclonal targets CD274
View all literature mentionsThis monoclonal targets CD54 (ICAM-1)
View all literature mentionsThis monoclonal targets Thy1
View all literature mentionsThis monoclonal targets Mouse/Rat CCR2 Allophycocyanin MAb (Clone 475301)
View all literature mentionsSoftware environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentions
Mus musculus with name B6.SJL-Ptprca Pepc
Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsMus musculus with name B6.129S6(C)-Zbtb46tm1.1Kmm/J from IMSR.
View all literature mentionsMus musculus with name B6.129S(C)-Batf3tm1Kmm/J from IMSR.
View all literature mentionsMus musculus with name B6.129S2-Cd207tm3.1(HBEGF/EGFP)Mal/J from IMSR.
View all literature mentionsMus musculus with name B6.129-Hif1atm3Rsjo/J from IMSR.
View all literature mentionsMus musculus with name B6.129S1-Irf4tm1Rdf/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Tg(Itgax-cre)1-1Reiz/J from IMSR.
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets CD90.2
View all literature mentionsThis monoclonal targets CD48
View all literature mentionsThis monoclonal targets CD172a
View all literature mentionsThis monoclonal targets Mouse/Rat CCR2 Allophycocyanin MAb (Clone 475301)
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