Plasmodium sporozoites inoculated by mosquitoes migrate to the liver and infect hepatocytes prior to release of merozoites that initiate symptomatic blood-stage malaria. Plasmodium parasites are thought to be restricted to hepatocytes throughout this obligate liver stage of development, and how liver-stage-expressed antigens prime productive CD8 T cell responses remains unknown. We found that a subset of liver-infiltrating monocyte-derived CD11c+ cells co-expressing F4/80, CD103, CD207, and CSF1R acquired parasites during the liver stage of malaria, but only after initial hepatocyte infection. These CD11c+ cells found in the infected liver and liver-draining lymph nodes exhibited transcriptionally and phenotypically enhanced antigen-presentation functions and primed protective CD8 T cell responses against Plasmodium liver-stage-restricted antigens. Our findings highlight a previously unrecognized aspect of Plasmodium biology and uncover the fundamental mechanism by which CD8 T cell responses are primed against liver-stage malaria antigens.
Pubmed ID: 30905437 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Commercial supplier and developer of in vivo antibodies. Provides antibodies and antibody production services.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
View all literature mentionsSoftware performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CSF1
View all literature mentionsThis monoclonal targets Tim-4
View all literature mentionsThis monoclonal targets CD207
View all literature mentionsThis monoclonal targets CD103
View all literature mentionsThis monoclonal targets CSF1R (CD115)
View all literature mentionsThis monoclonal targets CD207
View all literature mentionsThis monoclonal targets CD183 (CXCR3)
View all literature mentionsThis monoclonal targets CD186
View all literature mentionsThis monoclonal targets CD69
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD69
View all literature mentionsThis monoclonal targets CD86
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD192
View all literature mentionsThis monoclonal targets CD16/CD32
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets TNF-alpha
View all literature mentionsThis monoclonal targets CD40
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD90/CD90.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD90.2
View all literature mentionsThis monoclonal targets BrdU
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets IFN-gamma
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD64
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD115
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD14
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CX3CR1
View all literature mentionsThis monoclonal targets CSF1R
View all literature mentionsThis monoclonal targets I-A/I-E
View all literature mentionsThis monoclonal targets TER-119
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets Mouse Ly-6C
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets NK1.1
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsMus musculus with name B6.Cg-Tg(Itgax-Venus)1Mnz/J from IMSR.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware package for differential gene expression analysis based on the negative binomial distribution. Used for analyzing RNA-seq data for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates.
View all literature mentionsA web-based software application that enables users to analyze, integrate, and understand data derived from gene expression, microRNA, and SNP microarrays, metabolomics, proteomics, and RNA-Seq experiments, and small-scale experiments that generate gene and chemical lists. Users can search for targeted information on genes, proteins, chemicals, and drugs, and build interactive models of experimental systems. IPA allows exploration of molecular, chemical, gene, protein and miRNA interactions, creation of custom molecular pathways, and the ability to view and modify metabolic, signaling, and toxicological canonical pathways. In addition to the networks and pathways that can be created, IPA can provide multiple layering of additional information, such as drugs, disease genes, expression data, cellular functions and processes, or a researchers own genes or chemicals of interest.
View all literature mentionsA read summarization program, which counts mapped reads for the genomic features such as genes and exons.
View all literature mentionsSoftware performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsA collection of tools for flow cytometer and application setup, data acquisition, and data analysis that help streamline flow cytometry workflows. It provides features to help users integrate flow systems into new application areas, including index sorting for stem cell and single-cell applications, as well as automation protocols for high-throughput and robotic laboratories.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsSoftware for image capture, processing and analysis with Leica fluorescence and confocal microscopes.
View all literature mentionsMus musculus with name B6.FVB-1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/J from IMSR.
View all literature mentionsMus musculus with name B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ from IMSR.
View all literature mentionsMus musculus with name C57BL/6-Tg(TcraTcrb)1100Mjb/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J from IMSR.
View all literature mentionsMus musculus with name B6.129S2-Cd207tm3.1(HBEGF/EGFP)Mal/J from IMSR.
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsMus musculus with name C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J from IMSR.
View all literature mentionsMus musculus with name B6.129S2-Cd207tm3.1(HBEGF/EGFP)Mal/J from IMSR.
View all literature mentionsMus musculus with name B6.FVB-1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/J from IMSR.
View all literature mentionsMus musculus with name B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ from IMSR.
View all literature mentionsMus musculus with name C57BL/6-Tg(TcraTcrb)1100Mjb/J from IMSR.
View all literature mentionsThis monoclonal targets CD115
View all literature mentionsThis monoclonal targets CSF1R
View all literature mentions