While PARP inhibitors and CDK4/6 inhibitors, the two classes of FDA-approved agents, have shown promising clinical benefits, there is an urgent need to develop new therapeutic strategies to improve clinical response. Meanwhile, extending the utility of these inhibitors beyond their respective molecularly defined cancer types is challenging and will likely require biomarkers predictive of treatment response especially when used in a combination drug development setting.
Pubmed ID: 30898650 RIS Download
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Registry and results database of federally and privately supported clinical trials conducted in United States and around world. Provides information about purpose of trial, who may participate, locations, and phone numbers for more details. This information should be used in conjunction with advice from health care professionals.Offers information for locating federally and privately supported clinical trials for wide range of diseases and conditions. Research study in human volunteers to answer specific health questions. Interventional trials determine whether experimental treatments or new ways of using known therapies are safe and effective under controlled environments. Observational trials address health issues in large groups of people or populations in natural settings. ClinicalTrials.gov contains trials sponsored by National Institutes of Health, other federal agencies, and private industry. Studies listed in database are conducted in all 50 States and in 178 countries.
View all literature mentionsPrivately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related reagents used to study cell signaling pathways that impact human health.
View all literature mentionsProteintech Europe Ltd is an ISO 9001:2008 certified company
View all literature mentionsIntegrated database resource consisting of 16 main databases, broadly categorized into systems information, genomic information, and chemical information. In particular, gene catalogs in completely sequenced genomes are linked to higher-level systemic functions of cell, organism, and ecosystem. Analysis tools are also available. KEGG may be used as reference knowledge base for biological interpretation of large-scale datasets generated by sequencing and other high-throughput experimental technologies.
View all literature mentionsA portal that provides visualization, analysis and download of large-scale cancer genomics data sets.
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View all literature mentionsThis monoclonal targets Phospho-Rb (Ser807/811) (D20B12) XP Rabbit mAb
View all literature mentionsThis monoclonal targets Vinculin antibody produced in mouse
View all literature mentionsThis monoclonal targets Cleaved PARP (Asp214)
View all literature mentionsThis monoclonal targets Rad51
View all literature mentionsCell line SNU-119 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line COV362 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line Caov-3 is a Cancer cell line with a species of origin Homo sapiens (Human)
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View all literature mentionsCell line SK-OV-3 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis monoclonal targets c-Myc (D84C12) XP Rabbit mAb
View all literature mentionsCell line COV362 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line Caov-3 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis monoclonal targets Rad51
View all literature mentionsThis monoclonal targets Phospho-Rb (Ser807/811) (D20B12) XP Rabbit mAb
View all literature mentionsThis polyclonal targets Phospho-Histone H2A.X (Ser139)
View all literature mentions