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Most targeted therapies against cancer are designed to block growth factor-stimulated oncogenic growth. However, response rates are low, and resistance to therapy is high. One mechanism might relate to the ability of tumor cells to induce growth factor-independent proliferation (GFIP). This project aims to understand how (1) cancer cells preferentially derive a major growth advantage by using critical metabolic products of glucose, such as phosphoenolpyruvate (PEP), to drive proliferation and (2) esophageal squamous cell carcinoma (ESCC) cells, but not esophageal adenocarcinoma cells, can induce GFIP by using glycolysis to activate phosphohistidine (poHis)-mediated signaling through focal adhesion kinase (FAK).
Pubmed ID: 30836148 RIS Download
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Software environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
View all literature mentionsCommercial organization which provides reagents and services for molecular biology research. Its services include clone collections, microRNA solutions, genome editing, qPCR products, and fluorescent labeling and detection.
View all literature mentionsPrivately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related reagents used to study cell signaling pathways that impact human health.
View all literature mentionsSoftware repository for R packages related to analysis and comprehension of high throughput genomic data. Uses separate set of commands for installation of packages. Software project based on R programming language that provides tools for analysis and comprehension of high throughput genomic data.
View all literature mentionsA portal that provides visualization, analysis and download of large-scale cancer genomics data sets.
View all literature mentionsDatabase of all cell lines used in biomedical research which include immortalized cell lines, naturally immortal cell lines (stem cells), widely used and distributed finite life cell lines, vertebrate cell lines (majority being human, mouse, and rat), and invertebrate (insects and ticks) cell lines, as well as cell line synonyms. Each cell line is provided with the following information: the recommended name (the name which appears in the original publication), a list of synonyms, a unique accession number, comments on a number of topics including misspellings and gene transfection, information on the tissue/organ origin with the UBERON code, the NCI Thesaurus or Orphanet ORDO code for the disease(s) the individual suffered from (for cancer and human genetic disease lines only), the species of origin, the parent cell line, cross-references of sister cell lines, the sex of the individual, the category in which the cell line belongs (Adult stem cell; Cancer cell line; Embryonic stem cell; Factor-dependent cell line; Finite cell line; Hybrid cell line; Hybridoma; Induced pluripotent stem cell; Spontaneously immortalized cell line; Stromal cell line; Telomerase immortalized cell line; Transformed cell line; Undefined cell line type), web links, publication references, and/or cross-references to cell line catalogs/collections, ontologies, cell lines databases/resources, and to databases that list cell lines as samples.
View all literature mentionsCell line TE-10 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line KYAE-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line OACM5.1 C is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsCell line KYSE-520 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line TE-7 is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsCell line TE-9 is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsCell line KYSE-140 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line SK-GT-4 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line KYSE-180 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line FLO-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HET-1A is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line KYSE-150 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line TE-8 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line KYSE-70 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line TE-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line MCF-7 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line TE-9 is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsCell line TE-7 is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsCell line KYSE-520 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line OACM5.1 C is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsCell line KYSE-180 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line SK-GT-4 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line KYSE-140 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line TE-10 is a Cancer cell line with a species of origin Homo sapiens (Human)
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