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Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis.

British journal of pharmacology | 2019

Cystic fibrosis (CF) is a lethal autosomal recessive genetic disease that originates from the defective function of the CF transmembrane conductance regulator (CFTR) protein, a cAMP-dependent anion channel involved in fluid transport across epithelium. Because small synthetic transmembrane anion transporters (anionophores) can replace the biological anion transport mechanisms, independent of genetic mutations in the CFTR, such anionophores are candidates as new potential treatments for CF.

Pubmed ID: 30825185 RIS Download

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IGOR Pro (software resource)

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Software used for visualizing and graphing data, image processing, and programming. It is designed for use by scientists and engineers and supports large data sets, evenly spaced data, and various data import formats. The software includes a suite of image processing operations for image filtering, manipulation, and quantification and is completely programmable.

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CHO (cell line)

RRID:CVCL_0213

Cell line CHO is a Spontaneously immortalized cell line with a species of origin Cricetulus griseus (Chinese hamster)

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HEK293 (cell line)

RRID:CVCL_0045

Cell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)

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IGOR Pro (software resource)

RRID:SCR_000325

Software used for visualizing and graphing data, image processing, and programming. It is designed for use by scientists and engineers and supports large data sets, evenly spaced data, and various data import formats. The software includes a suite of image processing operations for image filtering, manipulation, and quantification and is completely programmable.

View all literature mentions