Searching across hundreds of databases
Adult neural stem cells and multiciliated ependymal cells are glial cells essential for neurological functions. Together, they make up the adult neurogenic niche. Using both high-throughput clonal analysis and single-cell resolution of progenitor division patterns and fate, we show that these two components of the neurogenic niche are lineally related: adult neural stem cells are sister cells to ependymal cells, whereas most ependymal cells arise from the terminal symmetric divisions of the lineage. Unexpectedly, we found that the antagonist regulators of DNA replication, GemC1 and Geminin, can tune the proportion of neural stem cells and ependymal cells. Our findings reveal the controlled dynamic of the neurogenic niche ontogeny and identify the Geminin family members as key regulators of the initial pool of adult neural stem cells.
Pubmed ID: 30824354 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Commercial vendor and service provider of laboratory reagents and antibodies. Supplier of scientific instrumentation, reagents and consumables, and software services.
View all literature mentionsAmerican chemical, life science and biotechnology company owned by Merck KGaA. Merger of Sigma Chemical Company and Aldrich Chemical Company. Provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name B6D2F1/J from IMSR.
View all literature mentionsThis monoclonal targets FOXJ1
View all literature mentionsThis polyclonal secondary targets IgG1
View all literature mentionsThis polyclonal targets Digoxigenin
View all literature mentionsThis polyclonal secondary targets IgG1
View all literature mentionsThis polyclonal secondary targets IgG2b
View all literature mentionsThis unknown targets IgG1
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgY (IgG) (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis monoclonal targets Tubulin Acetylated
View all literature mentionsThis monoclonal targets FGFR1OP monoclonal antibody (M01) clone 2B1
View all literature mentionsThis polyclonal targets ZO-1
View all literature mentionsThis monoclonal targets Glial Fibrillary Acidic Protein (GFAP)
View all literature mentionsThis monoclonal targets Tubulin, gamma
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis monoclonal targets CD24
View all literature mentionsThis polyclonal targets DsRed
View all literature mentionsMus musculus with name STOCK Igs2tm1(ACTB-EGFP.-tdTomato)Luo/J from IMSR.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsMus musculus with name STOCK Igs2tm2(ACTB-tdTomato.-EGFP)Luo/J from IMSR.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsMus musculus with name B6.129S2-Emx1tm1(cre)Krj/J from IMSR.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsMus musculus with name C57BL/6J-Tg(Nkx2-1-cre)2Sand/J from IMSR.
View all literature mentionsMus musculus with name B6;CBA-Tg(Gsx2-icre)1Kess/J from IMSR.
View all literature mentionsMus musculus with name B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name STOCK Igs2tm1(ACTB-EGFP.-tdTomato)Luo/J from IMSR.
View all literature mentionsMus musculus with name STOCK Igs2tm2(ACTB-tdTomato.-EGFP)Luo/J from IMSR.
View all literature mentionsThis monoclonal targets CD24
View all literature mentionsThis monoclonal targets FOXJ1
View all literature mentionsMus musculus with name B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J-Tg(Nkx2-1-cre)2Sand/J from IMSR.
View all literature mentionsMus musculus with name B6.129S2-Emx1tm1(cre)Krj/J from IMSR.
View all literature mentionsThis polyclonal targets DsRed
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis monoclonal targets Glial Fibrillary Acidic Protein (GFAP)
View all literature mentionsThis monoclonal targets FGFR1OP monoclonal antibody (M01) clone 2B1
View all literature mentionsThis monoclonal targets Tubulin, gamma
View all literature mentionsThis polyclonal targets ZO-1
View all literature mentionsThis polyclonal targets IgY (IgG) (H+L)
View all literature mentionsThis monoclonal targets Tubulin Acetylated
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG1
View all literature mentionsThis unknown targets IgG1
View all literature mentionsThis polyclonal secondary targets IgG1
View all literature mentionsThis monoclonal targets FOXJ1
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsMus musculus with name STOCK Igs2tm2(ACTB-tdTomato.-EGFP)Luo/J from IMSR.
View all literature mentionsMus musculus with name STOCK Igs2tm1(ACTB-EGFP.-tdTomato)Luo/J from IMSR.
View all literature mentionsMus musculus with name B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J-Tg(Nkx2-1-cre)2Sand/J from IMSR.
View all literature mentionsMus musculus with name B6;CBA-Tg(Gsx2-icre)1Kess/J from IMSR.
View all literature mentionsMus musculus with name B6.129S2-Emx1tm1(cre)Krj/J from IMSR.
View all literature mentionsThis polyclonal targets Digoxigenin
View all literature mentionsThis polyclonal secondary targets IgG2b
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
