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Novel molecular mechanisms in the inhibition of adrenal aldosterone synthesis: Action of tolvaptan via vasopressin V2 receptor-independent pathway.

British journal of pharmacology | 2019

We investigated the inhibitory effect and associated molecular mechanisms of tolvaptan on angiotensin II (AngII)-induced aldosterone production in vitro and in vivo.

Pubmed ID: 30801659 RIS Download

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GADD 153 (9C8) (antibody)

RRID:AB_783507

This monoclonal targets DDIT3

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AVPR V2 antibody (antibody)

RRID:AB_10892181

This polyclonal targets AVPR V2 antibody

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eIF2 alpha Antibody (antibody)

RRID:AB_2230924

This polyclonal targets eIF2 alpha

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Anti-β-Actin Antibody (antibody)

RRID:AB_476744

This monoclonal targets slightly modified β-cytoplasmic actin N-terminal peptide, Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys, conjugated to KLH

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p44/42 MAPK (Erk1/2) Antibody (antibody)

RRID:AB_330744

This polyclonal targets p44/42 MAPK (Erk1/2)

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Phospho-eIF2alpha (Ser51) Antibody (antibody)

RRID:AB_330951

This polyclonal targets Phospho-eIF2alpha (Ser51)

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Anti-CYP11B2, clone 41-17B (antibody)

RRID:AB_2783793

This monoclonal targets CYP11B2

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hCYP11B2 (antibody)

RRID:AB_2650562

This monoclonal targets CYP11B2

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CYP11B2 (antibody)

RRID:AB_2716717

This polyclonal targets CYP11B2

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SPSS (software resource)

RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

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ImageJ (software resource)

RRID:SCR_003070

Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.

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NCI-H295R (cell line)

RRID:CVCL_0458

Cell line NCI-H295R is a Cancer cell line with a species of origin Homo sapiens (Human)

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Slc:SD (organism)

RRID:RGD_12910483

Rattus norvegicus with name Slc:SD from RGD.

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